Ammonolysis and acylation of some novel B-enaminonitrites

In this work, the ammonolysis as well as acylation of some novel B- enaminonitrile are described. The reaction pathways were elucidated using t. l. c. technique and the chemical constitution of the products was established by spectral and elemental analysis

Proton magnetic resonance technique in determination of miquitazine

A new quantitative method for the determination of Mequitazine and its tablet form [primalan] [R] has been developed. The new method is based on comparison between the integral value of the doublet signal of the protons of the N-methylene at 10-position in Mequitazine and that singlet signal of the hexamine protons at 4.65 ppm. The new method is valuable for both powder and tablet forms, since it gives accurate and reproducible results

Reaction of enaminodimidones with x-cyanocinnamonitriles and their ester analogues

The reaction of several N-Substituted enaminodimidones with alpha, B-unsaturated nitriles is described. N-Aryl-enaminodimidones were found to react differently from their N-alkyl analogues giving the quinoline B-enaminotriles [3 a-m] and their esters with the former and the arylideneamine [4 a,b] in case of the latters. Likewise, the reaction products were found to be depending on polarity and temperature. 1[H] nmr, ir and microanalysis were consistent with the chemical structure of the products

Dimedone and its enamine derivatives in synthesis: reaction of 2,2-dibromo dimedone with ethyl bromoacetate and diethyl malonate [2]

[3 + 2] dipolar cycloaddition of 2,2-dibromodimedone and arylidenanilines did not give the expected adduct. Instead, the tetrasubstituted ethylenes were obtained. On the other h and, cyclocondensation of enaminodimedones with 1,2- and 1,3-bielectrophilic esters [viz. Ethyl bromoacetate and diethyl malonate] was described. IR, PMR, 13C-NMR and mass spectra were used to establish the chemical constitution of the products